CAS No.301856-25-7 | 5,7-difluoro-1h-indole
Name:5,7-difluoro-1h-indole CAS No.301856-25-7 MF:C8H5F2N MW:153.13 Purity:97% Package: 5g,25g,100g,500g,1kg,25kg Worldwide Delivery
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Product introduction
Introduction and application of CAS No.301856-25-7 | 5,7-difluoro-1h-indole
5,7-Difluoro-1H-indole is a metabolically stable, potent inhibitor of influenza A virus polymerase. It has been shown to be active in vivo against influenza A and B virus replication. The compound is undergoing clinical development for the treatment of influenza.
5,7-Difluoro-1H-indole inhibits the activity of the influenza virus polymerase by binding to the enzyme’s basic protein and blocking its active site. This prevents viral replication and can lead to therapeutic benefits in patients with influenza A or B infections.
Synonyms:
5,7-DIFLUOROINDOLE;
5,7-difluoroinde;
1H-Indole,5,7-difluoro-(9CI);
5,7-Difluoro-1H-Indole;1H-Indole, 5,7-difluoro-;
SWF-101;SW-101;
5,8-Difluoroindole
Specification of CAS No.301856-25-7 | 5,7-difluoro-1h-indole
|
ITEMS |
SPECIFICATION |
|
CAS No. |
301856-25-7 |
|
MF |
C8H5F2N |
|
MW |
153.13 |
|
Boiling point |
253.2±20.0 °C(Predicted) |
|
Density |
1.388±0.06 g/cm3(Predicted) |
|
acidity coefficient(pKa) |
14.71±0.30(Predicted) |
Package of CAS No.301856-25-7 | 5,7-difluoro-1h-indole
Package:100g; 500g; 1kg; 25kg;bulk package
Transportation: by courier/ by air/ by sea
Related Articles of CAS No.301856-25-7 | 5,7-difluoro-1h-indole
Design, synthesis, and biological evaluation of novel indoles targeting the influenza PB2 cap binding region
DC McGowan, W Balemans, W Embrechts… - Journal of medicinal …, 2019 - ACS Publications
… Specifically, a 5,7-difluoroindole derivative 11a was identified as a potent and metabolically
stable influenza inhibitor. 11a demonstrated a favorable oral pharmacokinetic profile and in …
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